Sh3glb2 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Involved in postsynaptic neurotransmitter receptor internalization. Is active in glutamatergic synapse and postsynaptic endocytic zone. Orthologous to human SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh3glb2 |
| Official Name | SH3 domain-containing GRB2-like endophilin B2 [Source:RGD Symbol;Acc:1305886] |
| Ensembl ID | ENSRNOG00000017295 |
| Bio databases IDs | |
| Aliases | SH3 domain-containing GRB2-like endophilin B2 |
| Synonyms | PP6569, PP9455, RRIG1, SH3 domain containing GRB2 like, endophilin B2, SH3 domain-containing GRB2-like endophilin B2, SH3-domain GRB2-like endophilin B2, SPAS-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sh3glb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- BAR domain
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Sh3glb2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cell surface
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sh3glb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cadherin binding