Sorbs2 Gene Summary [Rat]
Predicted to enable identical protein binding activity and protein domain specific binding activity. Involved in cell growth involved in cardiac muscle cell development. Located in dendrite and neuronal cell body. Orthologous to human SORBS2 (sorbin and SH3 domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sorbs2 |
| Official Name | sorbin and SH3 domain containing 2 [Source:RGD Symbol;Acc:620061] |
| Ensembl ID | ENSRNOG00000013391 |
| Bio databases IDs | |
| Aliases | sorbin and SH3 domain containing 2 |
| Synonyms | 2010203O03Rik, 9430041O17Rik, A530071H08, ARGBP2, LOC100503324, mKIAA0777, nArgBP2, PRO0618, Sh3-containing protein p4015, sorbin and SH3 domain containing 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sorbs2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of muscle
- structural constituent of cytoskeleton
- protein domain specific binding
- protein binding
- identical protein binding
- Sorbin homologous domain
- cytoskeletal adaptor
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- Alzheimer disease
- coronary artery disease
- non-insulin-dependent diabetes mellitus
- insomnia
- uterine leiomyoma
- leiomyomatosis
- fracture of bone
- ovarian carcinoma
- epithelial ovarian cancer
role in cell
- formation
- phosphorylation in
- quantity
- formation in
- abnormal morphology
- morphology
- complexity
- collapse
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- dendritic growth cone
- Cytoplasm
- focal adhesions
- actin cytoskeleton
- Nucleus
- myofilaments
- cytosol
- dendritic spines
- dendritic trees
- synapse
- intercalated disks
- Z line
- actin stress fibers
- anchoring junction
- perikaryon
- axons
- dendrites
- axon terminals
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sorbs2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- cytoskeleton organization
- cell growth involved in cardiac muscle cell development
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- Z disc
- perinuclear region of cytoplasm
- focal adhesion
- actin cytoskeleton
- neuronal cell body
- synapse
- apical plasma membrane
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of muscle
- RNA binding
- cytoskeletal adaptor activity
- structural constituent of cytoskeleton