Sbno2 Gene Summary [Rat]
Predicted to enable chromatin DNA binding activity and histone binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; macrophage activation involved in immune response; and regulation of DNA-templated transcription. Predicted to act upstream of or within bone mineralization; bone trabecula morphogenesis; and osteoclast fusion. Predicted to be active in nucleus. Orthologous to human SBNO2 (strawberry notch homolog 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sbno2 |
| Official Name | strawberry notch homolog 2 [Source:RGD Symbol;Acc:1307194] |
| Ensembl ID | ENSRNOG00000013987 |
| Bio databases IDs | |
| Aliases | strawberry notch homolog 2 |
| Synonyms | F730040C21, KIAA0963, RGD1307194, SNO, STNO, strawberry notch 2, strawberry notch homolog 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sbno2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal domain on Strawberry notch homolog
- P-loop containing NTP hydrolase pore-1
- transcription regulator
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- colorectal cancer
- non-insulin-dependent diabetes mellitus
- Crohn disease
- respiratory disorder
- ulcerative colitis
- systemic lupus erythematosus
- epithelial basal cell carcinoma
- non-melanoma skin cancer
- inflammatory bowel disease
regulates
- DCSTAMP
- RNA polymerase II
- DNA endogenous promoter
- DNA promoter
- NFkB (complex)
role in cell
- expression in
- activation
- differentiation
- abnormal morphology
- capivasertib resistance
- function
- fusion
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sbno2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoclast differentiation
- bone trabecula morphogenesis
- cellular response to lipopolysaccharide
- osteoclast fusion
- bone mineralization
- cellular response to interleukin-6
- negative regulation of transcription, DNA-dependent
- macrophage activation involved in immune response
- regulation of inflammatory response
- cellular response to interleukin-11
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- histone binding