Ccna1 Gene Summary [Rat]
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be located in microtubule cytoskeleton. Predicted to be part of cyclin A1-CDK2 complex and cyclin A2-CDK2 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human CCNA1 (cyclin A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccna1 |
| Official Name | cyclin A1 [Source:RGD Symbol;Acc:1310639] |
| Ensembl ID | ENSRNOG00000014052 |
| Bio databases IDs | |
| Aliases | cyclin A1 |
| Synonyms | CT146, CYCLIN A, cyclin A1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccna1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cyclin-A N-terminal APC/C binding region
- cyclin box
- Cyclin box fold superfamily
- Cyclin, N-terminal domain
- protein binding
- domain present in cyclins, TFIIB and Retinoblastoma
Pathways
Biological processes and signaling networks where the Ccna1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- obesity
- epithelial cancer
- neoplasia
- Parkinson disease
- facioscapulohumeral muscular dystrophy type 2
- colon epithelial cancer
- facioscapulohumeral muscular dystrophy
- prostate cancer
- neoplastic cell transformation
role in cell
- expression in
- activation in
- apoptosis
- proliferation
- cell cycle progression
- growth
- survival
- development
- G1/S phase transition
- meiosis I
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- microtubule cytoskeleton
- Cytoplasm
- cytosol
- nucleoplasm
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccna1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- spermatogenesis
- male meiosis I
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cyclin A1-CDK1 complex
- centrosome
- cyclin A2-CDK2 complex
- microtubule cytoskeleton
- cyclin A1-CDK2 complex
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cyclin-dependent protein kinase regulator activity