Ctsh Gene Summary [Rat]
Enables aminopeptidase activity; identical protein binding activity; and kininogen binding activity. Involved in several processes, including cellular response to thyroid hormone stimulus; response to odorant; and spermatogenesis. Located in cytoskeleton; extracellular space; and secretory granule. Biomarker of polycystic kidney disease. Orthologous to human CTSH (cathepsin H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctsh |
| Official Name | cathepsin H [Source:RGD Symbol;Acc:2447] |
| Ensembl ID | ENSRNOG00000014064 |
| Bio databases IDs | |
| Aliases | cathepsin H |
| Synonyms | ACC-4, ACC-5, CATHEPSIN H, CPSB, Pro-cathepsin H |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctsh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hormone binding
- Cathepsin propeptide inhibitor domain (I29)
- peptidase
- Peptidase_C1
- caspase activator
- protein binding
- cathepsin H
- HLA-A specific activating MHC class I receptor
- identical protein binding
- endopeptidase
- cysteine-type peptidase
- cysteine endopeptidase
- serine endopeptidase
- binding protein
- aminopeptidase
- apoptotic protease activator
Pathways
Biological processes and signaling networks where the Ctsh gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- non-insulin-dependent diabetes mellitus
- squamous cell cancer of the oral cavity
- cervical cancer
- epithelial cancer
- diabetes mellitus
- endometriosis
- Alzheimer disease
- acute graft-vs-host disease
- bipolar disorder
role in cell
- migration
- apoptosis
- proliferation
- activation in
- activation
- migration by
- invasion by
- migration in
- degradation
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- nuclear fraction
- mitochondrial fraction
- intracellular membrane-bounded organelle
- cytoplasmic ribonucleoprotein granule
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- organelle lumens
- podosomes
- endosomes
- lysosome
- axonemes
- cytosol
- acrosome
- outer dense fibers
- alveolar epithelial lamellar bodies
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctsh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- dichotomous subdivision of terminal units involved in lung branching
- surfactant homeostasis
- positive regulation of angiogenesis
- cellular response to thyroid hormone stimulus
- zymogen activation
- response to retinoic acid
- immune response
- neuropeptide catabolic process
- bradykinin catabolic process
- apoptotic process
- membrane protein proteolysis
- positive regulation of peptidase activity
- antigen processing and presentation
- positive regulation of epithelial cell migration
- proteolysis involved in cellular protein catabolic process
- adaptive immune response
- protein destabilization
- ERK1 and ERK2 cascade
- immune response-regulating signaling pathway
- metanephros development
- negative regulation of apoptotic process
- positive regulation of gene expression
- proteolysis
- T cell mediated cytotoxicity
- positive regulation of cell migration
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- cytosol
- secretory granule lumen
- alveolar lamellar body
- extracellular region
- lysosome
Molecular Function
What the gene product does at the molecular level
- HLA-A specific activating MHC class I receptor activity
- protein binding
- serine-type endopeptidase activity
- thyroid hormone binding
- cysteine-type endopeptidase activity
- endopeptidase activity
- aminopeptidase activity
- cysteine-type peptidase activity
- peptidase activity
- cysteine-type endopeptidase activator activity involved in apoptotic process