Lbp Gene Summary [Rat]
Enables lipopolysaccharide binding activity. Involved in several processes, including positive regulation of macrophage activation; positive regulation of phagocytosis, engulfment; and response to ethanol. Located in extracellular space. Used to study obesity. Biomarker of liver cirrhosis; metabolic dysfunction and alcohol associated liver disease; obstructive jaundice; and periodontitis. Orthologous to human LBP (lipopolysaccharide binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lbp |
| Official Name | lipopolysaccharide binding protein [Source:RGD Symbol;Acc:61865] |
| Ensembl ID | ENSRNOG00000014532 |
| Bio databases IDs | |
| Aliases | lipopolysaccharide binding protein |
| Synonyms | BPIFD2, Lipopolysaccharide binding, lipopolysaccharide binding protein, Ly88 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- binding protein
- protein binding
- receptor binding
- BPI
- lipopolysaccharide binding
- transporter
- coreceptor
Pathways
Biological processes and signaling networks where the Lbp gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Acute Phase Response Signaling
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-6 Signaling
- iNOS Signaling
- LPS-stimulated MAPK Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Phagosome Formation
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- obesity
- metastasis
- Crohn disease
- pneumonia
- major depression
- metabolic syndrome X
- facioscapulohumeral muscular dystrophy
- breast cancer
- non-psychotic major depressive disorder
role in cell
- expression in
- production in
- function
- chemotaxis
- activation
- binding
- response
- signaling
- response by
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- Nucleus
- azurophil granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of molecule of bacterial origin
- positive regulation of respiratory burst involved in inflammatory response
- macrophage activation involved in immune response
- opsonization
- cell surface pattern recognition receptor signaling pathway
- positive regulation of macrophage activation
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- defense response to Gram-positive bacterium
- negative regulation of tumor necrosis factor production
- lipopolysaccharide transport
- positive regulation of toll-like receptor 4 signaling pathway
- defense response to Gram-negative bacterium
- positive regulation of neutrophil chemotaxis
- acute-phase response
- leukocyte chemotaxis involved in inflammatory response
- cellular defense response
- positive regulation of interleukin-8 production
- cellular response to lipopolysaccharide
- cellular response to lipoteichoic acid
- innate immune response
- neutrophil chemotaxis
- lipopolysaccharide-mediated signaling pathway
- response to lipopolysaccharide
- positive regulation of interleukin-6 production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding
- lipoteichoic acid binding
- receptor binding
- lipopeptide binding
- lipopolysaccharide binding