Hivep1 Gene Summary [Rat]
Enables DNA binding activity. Predicted to be involved in BMP signaling pathway; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytosol; mitochondrion; and nuclear body. Predicted to be active in nucleus. Orthologous to human HIVEP1 (HIVEP zinc finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hivep1 |
| Official Name | HIVEP zinc finger 1 [Source:RGD Symbol;Acc:727847] |
| Ensembl ID | ENSRNOG00000014460 |
| Bio databases IDs | |
| Aliases | HIVEP zinc finger 1 |
| Synonyms | At-bp2, CIRIP, Cryabp1, CRYBP1, GAAP, HIVEP zinc finger 1, HIV type I ENHANCER binding protein 1, human immunodeficiency virus type I enhancer binding protein 1, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hivep1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- double-stranded DNA binding
- Zinc-finger double domain
- U1 zinc finger
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- COVID-19
- venous thromboembolism
- metabolic syndrome X
- schizophrenia
- Hutchinson-Gilford progeria syndrome
- colorectal cancer
- venous thrombosis
role in cell
- expression in
- differentiation
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hivep1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- BMP signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity