Ptk2b Gene Summary [Rat]
Enables several functions, including enzyme binding activity; neurotransmitter receptor regulator activity; and protein kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of apoptotic process; and positive regulation of metabolic process. Located in several cellular components, including apical dendrite; focal adhesion; and postsynaptic density. Part of NMDA selective glutamate receptor complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density, intracellular component. Used to study brain ischemia; diabetic angiopathy; and nephritis. Biomarker of anti-basement membrane glomerulonephritis; hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptk2b |
| Official Name | protein tyrosine kinase 2 beta [Source:RGD Symbol;Acc:628758] |
| Ensembl ID | ENSRNOG00000027839 |
| Bio databases IDs | |
| Aliases | protein tyrosine kinase 2 beta |
| Synonyms | CADTK, CAKB, CAK beta, CAK β, cell adhesion kinase β, E430023O05Rik, FADK2, FAK2, PKB, protein tyrosine kinase 2 beta, protein tyrosine kinase 2 β, PTK, PTK2 protein tyrosine kinase 2 beta, PTK2 protein tyrosine kinase 2 β, PYK2, RAFTK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptk2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Src binding domain
- protein kinase
- receptor activator
- CADTK-related non-kinase domain
- enzyme
- protein-tyrosine kinase
- Protein kinase domain
- proline rich domain
- FERM domain
- Focal adhesion targeting region
- FERM domain B-lobe
- Tyrosine kinase, catalytic domain
- ubiquitin protein ligase binding
- FERM central domain
- Band 4.1 homologues
- Protein kinase (unclassified specificity)
- protein kinase binding
- receptor regulator
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- enzyme binding
- paxillin-binding domain
- non-membrane spanning protein tyrosine kinase
- protein binding
- receptor binding
- Pleckstrin homology-like domain
- autophosphorylation site
- ionotropic glutamate receptor binding
- calmodulin regulated protein kinase
- FERM N-terminal domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- threonine-proline dipeptide repeat motif
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Ptk2b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Chemokine Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- ERK/MAPK Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- Gαq Signaling
- IL-15 Production
- IL-2 Signaling
- Natural Killer Cell Signaling
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- RANK Signaling in Osteoclasts
- Renin-Angiotensin Signaling
- RhoA Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of Tissue Factor in Cancer
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic non-squamous non-small cell lung cancer
- metastasis
- neoplasia
- schizophrenia
- inflammatory myofibroblastic tumor
- non-small cell lung cancer
- non-squamous lung carcinoma
- metastatic non-small cell lung cancer
- metastatic large cell lung carcinoma
- squamous cell lung cancer
role in cell
- phosphorylation in
- expression in
- production in
- proliferation
- differentiation
- apoptosis
- number
- growth
- formation
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- podosome belt
- organelle
- invadopodia
- presynaptic regions
- cell periphery
- perinuclear region
- postsynaptic region
- cellular membrane
- focal adhesions
- podosomes
- cell cortex
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- intercellular junctions
- cell-cell contacts
- cytosol
- membrane ruffles
- plasma membrane projections
- cell membrane-lagging edges
- nuclear clefts
- dendritic spines
- growth cone
- neurites
- synaptosomes
- synapse
- cellular protrusions
- membrane processes
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- postsynaptic density
- lamellipodia
- apical processes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptk2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- activation of Janus kinase activity
- signal complex assembly
- peptidyl-tyrosine phosphorylation
- positive regulation of translation
- epidermal growth factor receptor signaling pathway
- sprouting angiogenesis
- protein autophosphorylation
- negative regulation of potassium ion transport
- stress fiber assembly
- positive regulation of angiogenesis
- negative regulation of bone mineralization
- cortical cytoskeleton organization
- response to glucose stimulus
- positive regulation of cell growth
- marginal zone B cell differentiation
- response to hypoxia
- cellular response to fluid shear stress
- bone resorption
- regulation of synaptic plasticity
- apoptotic process
- long-term synaptic potentiation
- positive regulation of neuron projection development
- negative regulation of muscle cell apoptotic process
- positive regulation of synaptic transmission, glutamatergic
- long term synaptic depression
- ionotropic glutamate receptor signaling pathway
- focal adhesion assembly
- macromolecular complex assembly
- response to cocaine
- adaptive immune response
- response to cation stress
- response to hydrogen peroxide
- response to hormone stimulus
- cellular defense response
- vascular endothelial growth factor receptor signaling pathway
- tumor necrosis factor-mediated signaling pathway
- regulation of actin cytoskeleton organization
- oocyte maturation
- positive regulation of cell-matrix adhesion
- positive regulation of protein kinase activity
- response to immobilization stress
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- regulation of cell shape
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- positive regulation of nitric oxide biosynthetic process
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- response to cAMP
- response to xenobiotic stimulus
- protein phosphorylation
- response to mechanical stimulus
- negative regulation of neuron apoptotic process
- response to ethanol
- MAPK cascade
- integrin-mediated signaling pathway
- response to ischemia
- regulation of macrophage chemotaxis
- positive regulation of B cell chemotaxis
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- positive regulation of endothelial cell migration
- positive regulation of DNA biosynthetic process
- positive regulation of reactive oxygen species metabolic process
- negative regulation of myeloid cell differentiation
- signal transduction
- neuron projection development
- peptidyl-tyrosine autophosphorylation
- cell surface receptor signaling pathway
- blood vessel endothelial cell migration
- elevation of cytosolic calcium ion concentration
- regulation of release of sequestered calcium ion into cytosol
- cellular response to retinoic acid
- positive regulation of JNK cascade
- negative regulation of apoptotic process
- chemokine-mediated signaling pathway
- response to calcium ion
- positive regulation of actin filament polymerization
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of excitatory postsynaptic membrane potential
- regulation of cell adhesion
- glial cell proliferation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- neuronal cell body
- plasma membrane
- growth cone
- dendrite
- nucleus
- cytoskeleton
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- cell cortex
- dendritic spine
- cell body
- cytosol
- N-methyl-D-aspartate selective glutamate receptor complex
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- glutamate receptor binding
- ATP binding
- protein tyrosine kinase activity
- ubiquitin protein ligase binding
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- calmodulin-dependent protein kinase activity
- 3-phosphoinositide-dependent protein kinase binding