Ckmt1 Gene Summary [Rat]
Enables creatine kinase activity and identical protein binding activity. Involved in several processes, including cerebellum development; digestive tract development; and skeletal muscle tissue development. Located in mitochondrial inner-outer membrane contact site and perikaryon. Biomarker of status epilepticus. Orthologous to several human genes including CKMT1B (creatine kinase, mitochondrial 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ckmt1 |
| Official Name | creatine kinase, mitochondrial 1 [Source:RGD Symbol;Acc:61976] |
| Ensembl ID | ENSRNOG00000014573 |
| Bio databases IDs | |
| Aliases | creatine kinase, mitochondrial 1 |
| Synonyms | CKMT, CKMT1, CREATINE KINASE MITOCHONDRIAL, creatine kinase, mitochondrial 1, creatine kinase, mitochondrial 1B, Creatine kinase, mitochondrial 1, ubiquitous, Mia-CK, mi-CK, MTCK, ScCKmit, UbCKmit, UMTCK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ckmt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphagen (guanidino) kinases
- creatine kinase
- ATP:guanido phosphotransferase, N-terminal domain
- enzyme
- protein binding
- ATP:guanido phosphotransferase, C-terminal catalytic domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- gastric cancer
- metastasis
- pervasive developmental disorder
- organismal death
- growth failure
role in cell
- apoptosis
- binding in
- phosphorylation in
- proliferation
- aggregation
- morphology
- migration
- abnormal morphology
- opening
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
- synaptosomes
- organelle membrane contact site
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ckmt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphocreatine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- creatine kinase activity