Zfp423 Gene Summary [Rat]
Enables identical protein binding activity and sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in nephronophthisis 14. Orthologous to human ZNF423 (zinc finger protein 423). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp423 |
| Official Name | zinc finger protein 423 [Source:RGD Symbol;Acc:621664] |
| Ensembl ID | ENSRNOG00000014658 |
| Bio databases IDs | |
| Aliases | zinc finger protein 423 |
| Synonyms | ataxia1, AZ1, Ebfaz, hOAZ, JBTS19, mKIAA0760, NPHP14, nur12, OAZ, Olf1-Ebf associated zinc finger factor, Roaz, ZFP104, ZFP423, zinc finger protein 423 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zfp423 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- binding protein
- protein binding
- zinc finger domain
- sequence-specific DNA binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Zfp423 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- COVID-19
- Joubert syndrome type 19
- colorectal cancer
- focal cortical dysplasia type I
- gait disturbance
- idiopathic scoliosis
- organismal death
- Waldenström macroglobulinemia
- male pattern hair loss
role in cell
- apoptosis
- proliferation
- differentiation
- development
- assembly
- maturation
- arrangement
- transactivation in
- abnormal morphology
- mislocalization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zfp423 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of BMP signaling pathway
- Notch signaling pathway
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- nervous system development
- cell differentiation
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity