Peg3 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in autophagosome. Predicted to be active in nucleus. Orthologous to human PEG3 (paternally expressed 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Peg3 |
| Official Name | paternally expressed 3 [Source:RGD Symbol;Acc:2323590] |
| Ensembl ID | ENSRNOG00000014791 |
| Bio databases IDs | |
| Aliases | paternally expressed 3 |
| Synonyms | ASF-1, End4, GCAP4, LOC100363005, mKIAA0287, paternally expressed 3, PW1, Zfp102, ZKSCAN22, ZNF904, ZSCAN24 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Peg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Zinc finger, C2H2 type
- SCAN domain
- Proline-rich protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- acute myeloid leukemia
- metastatic colorectal cancer
- uterine serous papillary cancer
- adenomyosis
- glioblastoma
- glioblastoma cancer
- uterine leiomyoma
- leiomyomatosis
- endometrial cancer
role in cell
- quantity
- cell death
- expression in
- survival
- apoptosis
- degradation in
- signaling in
- accumulation in
- induction in
- autophagic flux in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Peg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- apoptotic process
- regulation of gene expression
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity