Mbd3 Gene Summary [Rat]
Predicted to enable methyl-CpG binding activity. Involved in several processes, including response to bisphenol A; response to estradiol; and ventricular cardiac muscle tissue development. Predicted to be located in cytoplasm; heterochromatin; and nucleoplasm. Predicted to be part of NuRD complex. Predicted to be active in nucleus. Biomarker of transient cerebral ischemia. Orthologous to human MBD3 (methyl-CpG binding domain protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mbd3 |
| Official Name | methyl-CpG binding domain protein 3 [Source:RGD Symbol;Acc:1307389] |
| Ensembl ID | ENSRNOG00000028956 |
| Bio databases IDs | |
| Aliases | methyl-CpG binding domain protein 3 |
| Synonyms | methyl-CpG binding domain protein 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mbd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyl-CpG binding
- p55-binding region of Methyl-CpG-binding domain proteins MBD
- coiled-coil domain
- protein binding
- MBD
- C-terminal domain of methyl-CpG binding protein 2 and 3
- DNA binding
Pathways
Biological processes and signaling networks where the Mbd3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- neoplasia
- liver cancer
- epithelial cancer
- prostate cancer
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- gastric cancer
- breast carcinoma
role in cell
- proliferation
- migration
- expression in
- differentiation
- phosphorylation in
- growth
- invasion by
- colony formation by
- remodeling
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- heterochromatin
- Cytoplasm
- centrosome
- nuclear foci
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mbd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell fate specification
- embryonic organ development
- methylation-dependent chromatin silencing
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- ventricular cardiac muscle tissue development
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- positive regulation of transcription, DNA-dependent
- regulation of stem cell differentiation
- response to estradiol stimulus
- response to nutrient levels
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- cytoplasm
- NuRD complex
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- nucleosomal DNA binding
- methyl-CpG binding