PEG3 Gene Summary [Human]
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | PEG3 |
| Official Name | paternally expressed 3 [Source:HGNC Symbol;Acc:HGNC:8826] |
| Ensembl ID | ENSG00000198300 |
| Bio databases IDs | |
| Aliases | paternally expressed 3 |
| Synonyms | ASF-1, End4, GCAP4, LOC100363005, mKIAA0287, paternally expressed 3, PW1, Zfp102, ZKSCAN22, ZNF904, ZSCAN24 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PEG3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Zinc finger, C2H2 type
- SCAN domain
- Proline-rich protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- acute myeloid leukemia
- metastatic colorectal cancer
- uterine serous papillary cancer
- adenomyosis
- glioblastoma
- glioblastoma cancer
- uterine leiomyoma
- leiomyomatosis
- endometrial cancer
role in cell
- quantity
- cell death
- expression in
- survival
- apoptosis
- degradation in
- signaling in
- accumulation in
- induction in
- autophagic flux in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PEG3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- apoptotic process
- regulation of gene expression
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity