Mesp1 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including heart development; negative regulation of cell fate specification; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including cardioblast migration; mesodermal cell migration; and signal transduction involved in regulation of gene expression. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human MESP1 (mesoderm posterior bHLH transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mesp1 |
| Official Name | mesoderm posterior bHLH transcription factor 1 [Source:RGD Symbol;Acc:1311751] |
| Ensembl ID | ENSRNOG00000014951 |
| Bio databases IDs | |
| Aliases | mesoderm posterior bHLH transcription factor 1 |
| Synonyms | bHLHc5, mesoderm posterior 1, mesoderm posterior bHLH transcription factor 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mesp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- protein binding
- Helix-loop-helix DNA-binding domain
- sequence-specific DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the Mesp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardia bifida
- growth failure
- congenital heart disease
- microcephaly
role in cell
- expression in
- differentiation
- generation
- migration
- development
- polarity
- epithelial-mesenchymal transition
- induction
- fate determination by
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mesp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction involved in regulation of gene expression
- sinoatrial node cell differentiation
- endothelial cell differentiation
- neurogenesis
- positive regulation of transcription from RNA polymerase II promoter
- cardiac atrium formation
- positive regulation of Notch signaling pathway
- cardiac ventricle formation
- heart morphogenesis
- heart induction
- lateral mesoderm development
- negative regulation of transcription, DNA-dependent
- cardiac vascular smooth muscle cell differentiation
- positive regulation of transcription, DNA-dependent
- positive regulation of hepatocyte differentiation
- heart looping
- mesoderm formation
- cardiac muscle cell differentiation
- somite rostral/caudal axis specification
- mesodermal cell migration
- growth involved in heart morphogenesis
- negative regulation of mesodermal cell fate specification
- cardiac cell fate determination
- embryonic heart tube morphogenesis
- negative regulation of endodermal cell fate specification
- cardioblast migration to the midline involved in heart field formation
- gastrulation
- regulation of transcription from RNA polymerase II promoter
- sinus venosus morphogenesis
- negative regulation of canonical Wnt receptor signaling pathway
- cardioblast anterior-lateral migration
- secondary heart field specification
- Notch signaling pathway
- positive regulation of striated muscle cell differentiation
- gene expression
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity