Mesp1

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; negative regulation of cell fate specification; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including cardioblast migration; mesodermal cell migration; and signal transduction involved in regulation of gene expression. Located in nucleus. Is expressed in several structures, including allantois; central nervous system; embryo mesenchyme; primitive streak; and sensory organ. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human MESP1 (mesoderm posterior bHLH transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mesp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Mesp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Mesp1 gene, providing context for its role in the cell.