Bmper Gene Summary [Rat]
Predicted to be involved in several processes, including blood vessel endothelial cell proliferation involved in sprouting angiogenesis; cell surface receptor protein serine/threonine kinase signaling pathway; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within inner ear development and negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human BMPER (BMP binding endothelial regulator). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmper |
| Official Name | BMP-binding endothelial regulator [Source:RGD Symbol;Acc:1563373] |
| Ensembl ID | ENSRNOG00000015357 |
| Bio databases IDs | |
| Aliases | BMP-binding endothelial regulator |
| Synonyms | 3110056H04Rik, BMP-binding endothelial regulator, CRIM3, CV-2, RGD1563373 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmper often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin Inhibitor like cysteine rich domain
- von Willebrand factor type C domain
- trypsin inhibitor-like cysteine rich domain
- von Willebrand factor type D domain
- protein binding
- von Willebrand factor (vWF) type D domain
- C8 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- Alzheimer disease
- major depression
- diaphanospondylodysostosis
- asthma
- hyperinsulinism
- bronchopulmonary dysplasia
- obesity
- androgenic alopecia
- hyperglycemia
role in cell
- activation in
- differentiation
- expression in
- phosphorylation in
- proliferation
- formation in
- inhibition in
- mineralization
- adhesion
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmper gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endothelial cell activation
- regulation of endothelial cell migration
- inner ear development
- regulation of protein localization
- SMAD protein signal transduction
- regulation of angiogenesis
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis
- negative regulation of BMP signaling pathway
- blood vessel development
- ureteric bud development
- BMP signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of SMAD protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix