Myl12a Gene Summary [Mouse]
Enables glutamate receptor binding activity. Acts upstream of or within protein localization to plasma membrane and regulation of cell shape. Located in Z disc and stress fiber. Part of myosin II complex. Orthologous to human MYL12A (myosin light chain 12A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myl12a |
| Official Name | myosin, light chain 12A, regulatory, non-sarcomeric [Source:MGI Symbol;Acc:MGI:1914518] |
| Ensembl ID | ENSMUSG00000024048 |
| Bio databases IDs | |
| Aliases | myosin, light chain 12A, regulatory, non-sarcomeric |
| Synonyms | 2900073G15Rik, myosin light chain 12A, myosin, light chain 12A, regulatory, non-sarcomeric, RGD1309537, Rlc-a |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myl12a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- EF-hand domain pair
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- enzyme binding
- receptor binding
Pathways
Biological processes and signaling networks where the Myl12a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Axonal Guidance Signaling
- Cardiac Hypertrophy Signaling
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- CXCR4 Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- Integrin Signaling
- PAK Signaling
- Phagosome Formation
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell cortex
- Z line
- actin stress fibers