Stag1 Gene Summary [Rat]
Predicted to enable chromatin binding activity. Predicted to be involved in mitotic spindle assembly and sister chromatid cohesion. Predicted to be located in cilium; mitotic spindle pole; and nuclear lumen. Predicted to be part of cohesin complex. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 47. Orthologous to human STAG1 (STAG1 cohesin complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stag1 |
| Official Name | stromal antigen 1 [Source:RGD Symbol;Acc:1310744] |
| Ensembl ID | ENSRNOG00000015389 |
| Bio databases IDs | |
| Aliases | stromal antigen 1 |
| Synonyms | COHESIN subunit SA-1, MRD47, SA-1, Scc3, SCC3A, STAG1 cohesin complex component, Stromal antigen 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stag1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromatin binding
- protein binding
- STAG domain
Pathways
Biological processes and signaling networks where the Stag1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- coronary artery disease
- pervasive developmental disorder
- schizophrenia
- major depression
- dental caries
- tumorigenesis
- COVID-19
- neuroticism
- prostate cancer
role in cell
- replication in
- cell proliferation
- replication
- assembly
- anaphase
- cohesion in
- segregation in
- cohesion
- aneuploidy
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cilia
- cytosol
- chromosome
- nucleoplasm
- nuclear bodies
- spindle pole
- nuclear matrix
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stag1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- sister chromatid cohesion
- establishment of mitotic sister chromatid cohesion
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- nuclear matrix
- cytosol
- cohesin complex
- chromosome
- mitotic cohesin complex
- chromosome, centromeric region
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding