STAG1
STAG1 Gene Summary
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | STAG1 |
| Official Name | stromal antigen 1 [Source:HGNC Symbol;Acc:HGNC:11354] |
| Ensembl ID | ENSG00000118007 |
| Bio databases IDs | |
| Aliases | stromal antigen 1, cohesin subunit SA-1 |
| Synonyms | COHESIN subunit SA-1,MRD47,SA-1,Scc3,SCC3A,STAG1 cohesin complex component,Stromal antigen 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromatin binding
- protein binding
- STAG domain
Pathways
Biological processes and signaling networks where the STAG1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- DDA1
- SMC3
- USP37
- KIF20B
- THAP1
- ANXA2
- DDX47
- EED
- PDS5B
- HDAC4
disease
- metabolic syndrome X
- coronary artery disease
- pervasive developmental disorder
- schizophrenia
- major depression
- dental caries
- tumorigenesis
- COVID-19
- neuroticism
- prostate cancer
regulated by
- CEBPB
- TNF
- TP53
- decitabine
- trichostatin A
- SP2509
- tazemetostat
- ADNP
- hydroxyurea
- TOB1
regulates
- PCDHB15
- PCDH7
- Pcdhb21
- Pcdhb17
- PCDH11X
- Pcdhb16
- PCDH17
role in cell
- replication in
- cell proliferation
- replication
- assembly
- anaphase
- cohesion in
- segregation in
- cohesion
- aneuploidy
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cilia
- cytosol
- chromosome
- nucleoplasm
- nuclear bodies
- spindle pole
- nuclear matrix
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the STAG1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell division
- sister chromatid cohesion
- establishment of mitotic sister chromatid cohesion
- spindle assembly involved in mitosis
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- nuclear body
- nuclear matrix
- cytosol
- cohesin complex
- chromosome
- mitotic cohesin complex
- chromosome, centromeric region
- chromatin
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- chromatin binding