Pcdh7 Gene Summary [Rat]
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to function in cell-cell recognition and adhesion. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Pcdh7 |
| Official Name | protocadherin 7 [Source:RGD Symbol;Acc:1303209] |
| Ensembl ID | ENSRNOG00000012367 |
| Bio databases IDs | |
| Aliases | protocadherin 7 |
| Synonyms | BH-Pc, BHPCDH, PPP1R120, protocadherin 7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcdh7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cadherin prodomain like
- Cadherin-like
- Cadherin repeat-like domain
- protein binding
- Protocadherin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- schizophrenia
- neoplasia
- idiopathic scoliosis
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- androgenic alopecia
- refractive error
- myopia
- early onset hypertension
role in cell
- apoptosis
- proliferation
- expression in
- migration
- colony formation
- invasion by
- cisplatin sensitivity
- molecular cleavage in
- navitoclax sensitivity
- interaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell surface
- cellular membrane
- alpha granules
- synaptic vesicles
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pcdh7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding