Myof Gene Summary [Rat]
Predicted to enable phospholipid binding activity. Predicted to be involved in membrane fusion; plasma membrane organization; and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to act upstream of or within cellular response to heat; glycerol metabolic process; and muscle cell development. Predicted to be located in caveola; cytoplasmic vesicle; and microtubule organizing center. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hereditary angioedema. Orthologous to human MYOF (myoferlin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myof |
| Official Name | myoferlin [Source:RGD Symbol;Acc:1564216] |
| Ensembl ID | ENSRNOG00000016117 |
| Bio databases IDs | |
| Aliases | myoferlin |
| Synonyms | 2310004N10Rik, 2310051D19Rik, DKFZP564E1616, E030042N20Rik, FER1L3, HAE7, Myoferlin, RGD1564216 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myof often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- Dysferlin domain, N-terminal region
- FerA (NUC095) domain
- FerI (NUC094) domain
- protein binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
- FerB (NUC096) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pancreatic cancer
- metastasis
- organismal death
- hereditary angioedema type VII
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- infection by HIV-1
role in cell
- accumulation in
- formation
- expression in
- fusion
- growth
- migration
- morphology
- production in
- proliferation
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- fusion site
- intracellular membrane-bounded organelle
- cilia
- cell surface
- cellular membrane
- Plasma Membrane
- basal bodies
- vesicles
- centrosome
- lysosome
- cell-cell contacts
- caveolae
- nucleoli
- nuclear envelope
- cytoplasmic vesicles
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Myof gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- plasma membrane repair
- muscle contraction
- blood circulation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- caveola
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- centriolar satellite
- cytoplasmic vesicle
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- phospholipid binding