Neto2 Gene Summary [Rat]
Predicted to enable ionotropic glutamate receptor binding activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Orthologous to human NETO2 (neuropilin and tolloid like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Neto2 |
| Official Name | neuropilin and tolloid like 2 [Source:RGD Symbol;Acc:1305310] |
| Ensembl ID | ENSRNOG00000016245 |
| Bio databases IDs | |
| Aliases | neuropilin and tolloid like 2 |
| Synonyms | 5530601C23Rik, BTCL2, NEOT2, neuropilin and tolloid like 2, neuropilin (NRP) and tolloid (TLL)-like 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Neto2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CUB
- LDLa
- protein binding
- ionotropic glutamate receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- angiomatosis
- adenoma formation
- hemangioma
- aldosterone producing adrenocortical adenoma
- glioblastoma
- glioblastoma cancer
- preeclampsia
- Cornelia de Lange syndrome
role in cell
- desensitization in
- neurite outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- synaptic membrane
- synaptosomes
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Neto2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
Molecular Function
What the gene product does at the molecular level
- ionotropic glutamate receptor binding