Arhgef28 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cell morphogenesis and regulation of Rho protein signal transduction. Predicted to act upstream of or within central nervous system neuron axonogenesis and neurofilament cytoskeleton organization. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human ARHGEF28 (Rho guanine nucleotide exchange factor 28). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef28 |
| Official Name | Rho guanine nucleotide exchange factor 28 [Source:RGD Symbol;Acc:1307061] |
| Ensembl ID | ENSRNOG00000016544 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor 28 |
| Synonyms | 9230110L08RIK, D13Bwg1089e, p190RHOGEF, RGNEF, RhoGEF, Rho guanine nucleotide exchange factor 28, Rhoip2, RIP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgef28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- protein kinase C conserved region 1 (C1 domain) superfamily
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Dbl homology domain
- RhoGEF domain
Pathways
Biological processes and signaling networks where the Arhgef28 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gallstone
- hearing loss
- colorectal cancer
- age-related hearing loss
- amyotrophic lateral sclerosis
- chronic obstructive pulmonary disease
- acute myeloid leukemia
- Hodgkin lymphoma
- Hodgkin disease
role in cell
- phosphorylation in
- migration
- binding in
- formation
- regulation
- migration by
- organization
- axonogenesis
- morphology
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgef28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rho protein signal transduction
- central nervous system neuron axonogenesis
- neurofilament cytoskeleton organization
- regulation of small GTPase mediated signal transduction
- cell morphogenesis
- ephrin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- RNA binding
- metal ion binding
- guanyl-nucleotide exchange factor activity