Tmeff2 Gene Summary [Rat]
Predicted to be involved in cell differentiation. Predicted to act upstream of or within negative regulation of cell migration; negative regulation of cellular component organization; and wound healing, spreading of cells. Predicted to be located in membrane. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in prostate cancer and urinary bladder cancer. Orthologous to human TMEFF2 (transmembrane protein with EGF like and two follistatin like domains 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmeff2 |
| Official Name | transmembrane protein with EGF-like and two follistatin-like domains 2 [Source:RGD Symbol;Acc:1308839] |
| Ensembl ID | ENSRNOG00000016623 |
| Bio databases IDs | |
| Aliases | transmembrane protein with EGF-like and two follistatin-like domains 2 |
| Synonyms | 4832418D20Rik, 7630402F16RIK, CT120.2, HPP1, LOC108167624, TENB2, TOMOREGULIN, TPEF, TR, TR-2, transmembrane protein with EGF-like and two follistatin-like domains 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmeff2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ectodomain
- protein binding
- KAZAL_FS
Pathways
Biological processes and signaling networks where the Tmeff2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- sudden cardiac arrest
- side effect
- ischemic stroke
- adenomyosis
- pigmented villonodular synovitis
role in cell
- apoptosis
- proliferation
- migration
- cell cycle progression
- assembly
- colony formation by
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmeff2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing, spreading of cells
- negative regulation of stress fiber assembly
- multicellular organismal development
- negative regulation of integrin biosynthetic process
- cell differentiation
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding