Atg13 Gene Summary [Rat]
Predicted to enable protein kinase binding activity and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including macroautophagy; positive regulation of protein targeting to mitochondrion; and response to mitochondrial depolarisation. Predicted to act upstream of or within autophagosome assembly. Predicted to be located in mitochondrion. Predicted to be part of Atg1/ULK1 kinase complex. Predicted to be active in autophagosome; cytosol; and phagophore assembly site membrane. Orthologous to human ATG13 (autophagy related 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg13 |
| Official Name | autophagy related 13 [Source:RGD Symbol;Acc:1310685] |
| Ensembl ID | ENSRNOG00000016984 |
| Bio databases IDs | |
| Aliases | autophagy related 13 |
| Synonyms | 1110053A20Rik, autophagy related 13, D2Ertd391e, Harbi1, Harbi1l, KIAA0652, PARATARG8, RGD1310685 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atg13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- protein kinase binding
- protein binding
- Autophagy-related protein 13
Pathways
Biological processes and signaling networks where the Atg13 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- headache
- non-melanoma skin cancer
role in cell
- phosphorylation in
- proliferation
- autophagy in
- formation
- cell death
- binding in
- assembly
- autophagy by
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atg13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- positive regulation of autophagy
- piecemeal microautophagy of nucleus
- protein localization to pre-autophagosomal structure
- negative regulation of cell proliferation
- macromitophagy
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- pre-autophagosomal structure membrane
- cytoplasm
- pre-autophagosomal structure
- mitochondrion
- cytosol
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein serine/threonine kinase activator activity
- protein binding
- protein kinase regulator activity