Mlst8 Gene Summary [Rat]
Predicted to enable protein serine/threonine kinase activator activity and protein-macromolecule adaptor activity. Predicted to be involved in TOR signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Predicted to act upstream of or within positive regulation of actin filament polymerization and positive regulation of peptidyl-tyrosine phosphorylation. Located in cytoplasm. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mlst8 |
| Official Name | MTOR associated protein, LST8 homolog [Source:RGD Symbol;Acc:69242] |
| Ensembl ID | ENSRNOG00000009667 |
| Bio databases IDs | |
| Aliases | MTOR associated protein, LST8 homolog |
| Synonyms | 0610033N12Rik, GbetaL, GBL, GβL, LST8, MTOR associated protein, LST8 homolog, MTOR associated protein, LST8 homolog (S. cerevisiae), POP3, WAT1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mlst8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- WD40 repeats
- protein binding activity, bridging
- WD domain, G-beta repeat
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Mlst8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Autophagy
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- HER-2 Signaling in Breast Cancer
- IL-15 Signaling
- IL-4 Signaling
- mTOR Signaling
- Polyamine Regulation in Colon Cancer
- T Cell Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- organismal death
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- expression in
- proliferation
- phosphorylation in
- migration
- growth
- invasion by
- differentiation
- association
- size
- reorganization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mlst8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- TOR signaling cascade
- response to DNA damage stimulus
- positive regulation of glycolysis
- positive regulation of lipid biosynthetic process
- positive regulation of cell growth
- regulation of actin cytoskeleton organization
- cellular response to osmotic stress
- cellular response to nutrient levels
- negative regulation of apoptotic process
- negative regulation of autophagy
- positive regulation of actin filament polymerization
- cellular response to hypoxia
- positive regulation of TOR signaling cascade
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- TORC2 complex
- cytoplasm
- cytosol
- TORC1 complex
- lysosomal membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine kinase activator activity
- protein binding