Ubash3b Gene Summary [Rat]
Enables ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including collagen-activated tyrosine kinase receptor signaling pathway; negative regulation of bone resorption; and platelet aggregation. Predicted to act upstream of or within several processes, including negative regulation of osteoclast differentiation; negative regulation of platelet aggregation; and platelet activation. Predicted to be active in cytoplasm. Orthologous to human UBASH3B (ubiquitin associated and SH3 domain containing B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubash3b |
| Official Name | ubiquitin associated and SH3 domain containing, B [Source:RGD Symbol;Acc:1310357] |
| Ensembl ID | ENSRNOG00000008187 |
| Bio databases IDs | |
| Aliases | ubiquitin associated and SH3 domain containing, B |
| Synonyms | 2810457I06Rik, KIAA1959, p70, RGD1310357, STS-1, TULA-2, ubiquitin associated and SH3 domain containing B, ubiquitin associated and SH3 domain containing, B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ubash3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- ubiquitin protein ligase binding
- protein-tyrosine-phoshatase
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- phosphoprotein binding
- enzyme
- Histidine phosphatase domain
- protein binding
- alpha-ribazole phosphatase
- identical protein binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Ubash3b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- cardiovascular disorder
- experimental autoimmune encephalomyelitis
- systemic lupus erythematosus
- preeclampsia
- cerebral atherosclerosis
role in cell
- differentiation
- phosphorylation in
- activation in
- tyrosine phosphorylation in
- proliferation
- number
- signaling in
- autophagy by
- aggregation
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ubash3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of release of sequestered calcium ion into cytosol
- negative regulation of signal transduction
- regulation of osteoclast differentiation
- negative regulation of platelet aggregation
- negative regulation of osteoclast differentiation
- collagen-activated tyrosine kinase receptor signaling pathway
- negative regulation of bone resorption
- platelet aggregation
- negative regulation of protein kinase activity
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- protein tyrosine phosphatase activity
- phosphoprotein binding