Apoa4 Gene Summary [Rat]
Predicted to enable several functions, including cation binding activity; cholesterol transfer activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in peripheral nervous system axon regeneration and response to triglyceride. Part of chylomicron. Is active in synapse. Biomarker of major depressive disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease; colitis; myocardial infarction; and ulcerative colitis. Orthologous to human APOA4 (apolipoprotein A4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apoa4 |
| Official Name | apolipoprotein A4 [Source:RGD Symbol;Acc:2132] |
| Ensembl ID | ENSRNOG00000055909 |
| Bio databases IDs | |
| Aliases | apolipoprotein A4 |
| Synonyms | APOA-IV, apolipoprotein A4, APOLIPOPROTEIN A-IV |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Apoa4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- copper ion binding
- phospholipid binding
- binding protein
- lipid binding
- protein homodimerization
- antioxidant enzyme
- protein binding
- enzyme activator activity
- identical protein binding
- Apolipoprotein A1/A4/E domain
- transporter
Pathways
Biological processes and signaling networks where the Apoa4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- schizophrenia
- diabetes mellitus
- Huntington disease
- Alzheimer disease
- aortic valve calcification
- autosomal dominant tubulointerstitial kidney disease
- complete testicular feminization syndrome
- colitis
- systemic sclerosis
role in cell
- expression in
- adhesion
- cell-cell adhesion
- number
- efflux in
- transactivation in
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi-enriched fraction
- Cytoplasm
- cell surface
- cellular membrane
- cytosol
- endoplasmic reticulum lumen
- synapse
- early endosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Apoa4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- very-low-density lipoprotein particle remodeling
- chylomicron remodeling
- high-density lipoprotein particle remodeling
- regulation of cholesterol transport
- cholesterol metabolic process
- response to lipid hydroperoxide
- lipoprotein metabolic process
- acylglycerol homeostasis
- cholesterol homeostasis
- leukocyte cell-cell adhesion
- positive regulation of fatty acid biosynthetic process
- reverse cholesterol transport
- negative regulation of plasma lipoprotein particle oxidation
- positive regulation of triglyceride catabolic process
- regulation of intestinal cholesterol absorption
- positive regulation of lipoprotein lipase activity
- response to stilbenoid
- protein-lipid complex assembly
- peripheral nervous system axon regeneration
- lipid homeostasis
- hydrogen peroxide catabolic process
- lipid transport
- innate immune response in mucosa
- phosphatidylcholine metabolic process
- removal of superoxide radicals
- lipid catabolic process
- cholesterol efflux
- chylomicron assembly
- response to triglyceride
- phospholipid efflux
Cellular Component
Where in the cell the gene product is active
- very-low-density lipoprotein particle
- chylomicron
- high-density lipoprotein particle
- low-density lipoprotein particle
- synapse
- extracellular region
- cell surface
- endoplasmic reticulum lumen
- early endosome
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- copper ion binding
- antioxidant activity
- lipid transporter activity
- phosphatidylcholine-sterol O-acyltransferase activator activity
- lipid binding
- phosphatidylcholine binding
- phospholipid binding