Ncr1 Gene Summary [Rat]
Predicted to be involved in cellular defense response; regulation of natural killer cell mediated cytotoxicity; and signal transduction. Predicted to act upstream of or within defense response to virus and detection of virus. Predicted to be located in cell surface. Predicted to be part of SWI/SNF complex. Predicted to be active in plasma membrane. Biomarker of acquired immunodeficiency syndrome; anogenital venereal wart; hepatitis C; and lymphoproliferative syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | Ncr1 |
| Official Name | natural cytotoxicity triggering receptor 1 [Source:RGD Symbol;Acc:621288] |
| Ensembl ID | ENSRNOG00000018458 |
| Bio databases IDs | |
| Aliases | natural cytotoxicity triggering receptor 1 |
| Synonyms | Ar1, CD335, KILR-1, LY94, natural cytotoxicity triggering receptor 1, NK-p46 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ncr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- membrane-proximal domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Ncr1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- systemic lupus erythematosus
- acute myeloid leukemia
- lung metastasis
- acute-on-chronic liver failure
- sepsis
- Tourette syndrome
- infection by virus
role in cell
- expression in
- signaling in
- migration
- production in
- activation in
- killing
- phosphorylation in
- cytotoxicity
- activity
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ncr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular defense response
- immune response-regulating signaling pathway
- signal transduction
- natural killer cell activation
- regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding