Ccnh Gene Summary [Rat]
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity and kinase activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in several processes, including protein stabilization; regulation of G1/S transition of mitotic cell cycle; and transcription initiation at RNA polymerase II promoter. Predicted to be located in male germ cell nucleus and nucleoplasm. Predicted to be part of CAK-ERCC2 complex; transcription factor TFIIH core complex; and transcription factor TFIIK complex. Predicted to be active in nucleus. Biomarker of transient cerebral ischemia. Orthologous to human CCNH (cyclin H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccnh |
| Official Name | cyclin H [Source:RGD Symbol;Acc:69419] |
| Ensembl ID | ENSRNOG00000031656 |
| Bio databases IDs | |
| Aliases | cyclin H |
| Synonyms | 6330408H09Rik, CAK, CycH, cyclin H, p34, p37 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccnh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase
- protein serine/threonine kinase
- transcription regulator
- Cyclin box fold superfamily
- cyclin ccl1
- Cyclin C-terminal domain
- domain present in cyclins, TFIIB and Retinoblastoma
- protein binding
- general RNA polymerase II transcription factor
Pathways
Biological processes and signaling networks where the Ccnh gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- benign neoplasia
- capillary malformation-arteriovenous malformation
- capillary malformation-arteriovenous malformation 1
- vascular malformation
- Klippel-Trenaunay syndrome
- hereditary disorder
- susceptibility to basal cell carcinoma type 1
- hereditary hemorrhagic telangiectasia
- capillary hemangioma formation
- infantile hemangioma formation
role in cell
- phosphorylation in
- expression in
- degradation in
- proliferation
- differentiation
- binding in
- invasiveness
- replication in
- dimerization in
- migratory capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccnh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of G1/S transition of mitotic cell cycle
- protein stabilization
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cyclin-dependent protein kinase holoenzyme complex
- core TFIIH complex
- TFIIK complex
- holo TFIIH complex
- CAK-ERCC2 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclin-dependent protein kinase regulator activity
- protein binding
- general RNA polymerase II transcription factor activity