Nutf2 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; nuclear import signal receptor activity; and small GTPase binding activity. Acts upstream of or within protein import into nucleus. Predicted to be located in cytosol; nuclear outer membrane; and nucleoplasm. Predicted to be part of nuclear pore central transport channel. Is expressed in several structures, including alimentary system; central nervous system; integumental system; salivary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nutf2 |
| Official Name | nuclear transport factor 2 [Source:MGI Symbol;Acc:MGI:1915301] |
| Ensembl ID | ENSMUSG00000008450 |
| Bio databases IDs | |
| Aliases | nuclear transport factor 2 |
| Synonyms | 2700067I02Rik, NTF-2, Ntf3, nuclear transport factor 2, PP15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nutf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of nuclear pore
- enzyme binding
- protein binding
- NTF2_like
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Hutchinson-Gilford progeria syndrome
- Waldenström macroglobulinemia
role in cell
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- outer nuclear membrane
- nuclear envelope
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nutf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to nuclear pore
- protein import into nucleus
- protein export from nucleus
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear inner membrane
- nuclear membrane
- extracellular vesicular exosome
- cytosol
- nuclear outer membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural constituent of nuclear pore
- small GTPase binding