Eya2 Gene Summary [Rat]
Predicted to enable histone H2AXY142 phosphatase activity; magnesium ion binding activity; and protein tyrosine phosphatase activity. Predicted to be involved in cell differentiation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of DNA repair. Predicted to act upstream of or within apoptotic signaling pathway; protein dephosphorylation; and striated muscle tissue development. Predicted to be located in cytosol. Predicted to be active in nucleus. Orthologous to human EYA2 (EYA transcriptional coactivator and phosphatase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eya2 |
| Official Name | EYA transcriptional coactivator and phosphatase 2 [Source:RGD Symbol;Acc:620096] |
| Ensembl ID | ENSRNOG00000019203 |
| Bio databases IDs | |
| Aliases | EYA transcriptional coactivator and phosphatase 2 |
| Synonyms | EAB1, EYA transcriptional coactivator and phosphatase 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eya2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine-phoshatase
- Pst domain
- transcription activation domain
- enzyme
- protein binding
- magnesium ion binding
- phosphatase domain
- protein phosphatase
- phosphatase
- Eya domain
- Haloacid Dehalogenase-like Hydrolases
- haloacid dehalogenase-like hydrolase
- eyes absent protein conserved domain
Pathways
Biological processes and signaling networks where the Eya2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- epithelial neoplasia
- abdominal cancer
- non-insulin-dependent diabetes mellitus
- nonalcoholic fatty liver disease
- metabolic syndrome X
- liver neoplasia
- allergy
- asthma
role in cell
- apoptosis
- expression in
- activation in
- proliferation
- phosphorylation in
- migration
- invasion by
- quantity
- modification
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eya2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- DNA repair
- chromatin remodeling
- striated muscle tissue development
- cell differentiation
- anatomical structure development
- extrinsic apoptotic signaling pathway in absence of ligand
- mesodermal cell fate specification
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- protein binding
- protein tyrosine phosphatase activity