Add2 Gene Summary [Rat]
Predicted to enable cytoskeletal protein binding activity; protein dimerization activity; and protein kinase binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in monoatomic ion transport. Is active in glutamatergic synapse and postsynapse. Used to study hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and hypertension. Orthologous to human ADD2 (adducin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Add2 |
| Official Name | adducin 2 [Source:RGD Symbol;Acc:2042] |
| Ensembl ID | ENSRNOG00000015903 |
| Bio databases IDs | |
| Aliases | adducin 2 |
| Synonyms | 2900072M03RIK, add97, ADDB, adducin 2, adducin 2 (beta), adducin 2 (β), beta 4 ADDUCIN, beta-ADD, beta ADDUCIN, β 4 ADDUCIN, β-ADD, β ADDUCIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Add2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- protein kinase binding
- oligomerization domain
- spectrin binding
- head domain
- actin filament binding
- Aldolase_II
- structural constituent of cytoskeleton
- Class II Aldolase and Adducin N-terminal domain
- MARCKS-related domain
- actin binding
- protein homodimerization
- tail domain
- neck domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Add2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- anisopoikilocytosis
- microcytosis
- acute myeloid leukemia
- anemia
- IgA nephropathy
- hypertension
- spherocytosis
- diastolic hypertension
- small cell lung cancer
role in cell
- quantity
- expression in
- migration
- growth
- morphology
- abnormal morphology
- cell tethering or rolling by
- transmission
- assembly
- hematopoiesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- glutaminergic synapse
- postsynaptic region
- cellular membrane
- Nucleus
- Plasma Membrane
- cell-cell contacts
- cytosol
- cytoplasmic vesicles
- membrane rafts
- postsynaptic density
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Add2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- barbed-end actin filament capping
- synapse assembly
- positive regulation of protein binding
- macromolecular complex assembly
- hemopoiesis
- leukocyte migration
- leukocyte tethering or rolling
- actin cytoskeleton organization
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytoskeleton
- cytoplasmic vesicle
- cytosol
- F-actin capping protein complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein kinase binding
- calmodulin binding
- protein homodimerization activity
- actin binding
- spectrin binding
- protein heterodimerization activity
- protein dimerization activity
- structural constituent of cytoskeleton