Pld2 Gene Summary [Rat]
Enables phospholipase D activity and protein kinase C binding activity. Involved in several processes, including cellular response to phorbol 13-acetate 12-myristate; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of vesicle-mediated transport. Located in caveola; lamellipodium; and sarcolemma. Biomarker of congestive heart failure. Orthologous to human PLD2 (phospholipase D2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pld2 |
| Official Name | phospholipase D2 [Source:RGD Symbol;Acc:3350] |
| Ensembl ID | ENSRNOG00000019604 |
| Bio databases IDs | |
| Aliases | phospholipase D2 |
| Synonyms | phospholipase D2, PLD1C, Pldc |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pld2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phospholipase D Active site motif
- phospholipase D
- conserved region CRIV
- catalytic domain
- protein kinase C binding
- CR1 domain
- CR2 domain
- CR3 domain
- enzyme
- protein binding
- Pleckstrin homology-like domain
- Catalytic domain of phospholipase D superfamily proteins
- PH domain
- PLD-like domain
- The Phox Homology domain, a phosphoinositide binding module
- PX domain
- phagocytic oxidase domain
Pathways
Biological processes and signaling networks where the Pld2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- memory deficits
- diabetes mellitus
- neoplasia
- colon neoplasm
- colorectal neoplasia
- systemic lupus erythematosus
- vascular leak syndrome
- endometrioma
role in cell
- activation in
- apoptosis
- number
- chemotaxis
- expression in
- phagocytosis by
- phosphorylation in
- binding in
- proliferation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- detergent resistant lipid raft fraction
- perinuclear Golgi regions
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- endoplasmic reticulum membrane
- caveolae
- Golgi cisternal rims
- perinucleolar compartments
- synapse
- sarcolemma
- Z line
- peri-Golgi vesicles
- perinuclear vesicles
- brush border
- Golgi vesicles
- medial Golgi cisternae
- cis Golgi cisternae
- lamellipodia
- detergent-soluble fraction
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pld2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- small GTPase mediated signal transduction
- phospholipid catabolic process
- regulation of vesicle-mediated transport
- Fc-gamma receptor signaling pathway involved in phagocytosis
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol binding
- phospholipase D activity
- NAPE-specific phospholipase D activity