Ogdhl Gene Summary [Rat]
Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in 2-oxoglutarate metabolic process and tricarboxylic acid cycle. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome. Orthologous to human OGDHL (oxoglutarate dehydrogenase L). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ogdhl |
| Official Name | oxoglutarate dehydrogenase-like [Source:RGD Symbol;Acc:1310916] |
| Ensembl ID | ENSRNOG00000019955 |
| Bio databases IDs | |
| Aliases | oxoglutarate dehydrogenase-like |
| Synonyms | oxoglutarate dehydrogenase L, oxoglutarate dehydrogenase-like, YOBELN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ogdhl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2-oxoglutarate dehydrogenase C-terminal
- 2-oxoglutarate dehydrogenase N-terminus
- 2-oxoglutarate dehydrogenase, E1 component
- Transketolase, pyrimidine binding domain
- TPP_enzymes
- Dehydrogenase E1 component
- enzyme
- protein binding
- kgd
- thiamine pyrophosphate-dependent enzyme pyrimidine binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- Yoon-Bellen neurodevelopmental syndrome
- renal clear cell adenocarcinoma
- renal clear cell cancer
- Alzheimer disease
- non-insulin-dependent diabetes mellitus
- osteoporosis
- hepatitis B virus-related hepatocellular carcinoma
role in cell
- expression in
- proliferation
- migration
- accumulation in
- ubiquitination in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ogdhl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycolysis
- tricarboxylic acid cycle
- 2-oxoglutarate metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- oxoglutarate dehydrogenase complex
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- thiamine pyrophosphate binding
- protein binding
- metal ion binding
- oxoglutarate dehydrogenase (succinyl-transferring) activity