Il4i1 Gene Summary [Rat]
Predicted to enable L-amino-acid oxidase activity. Predicted to be involved in erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process; negative regulation of T cell mediated immune response to tumor cell; and regulation of lymphocyte activation. Predicted to act upstream of or within aromatic amino acid metabolic process. Predicted to be located in several cellular components, including acrosomal vesicle; immunological synapse; and sperm midpiece. Orthologous to human IL4I1 (interleukin 4 induced 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il4i1 |
| Official Name | interleukin 4 induced 1 [Source:RGD Symbol;Acc:1304831] |
| Ensembl ID | ENSRNOG00000020148 |
| Bio databases IDs | |
| Aliases | interleukin 4 induced 1 |
| Synonyms | Aromatic l-amino acid oxidase, FIG1, hIL4I1, interleukin 4 induced 1, LAAO, LAO, LOC100364826 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il4i1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- L-amino-acid oxidase
- enzyme
- protein binding
- Flavin containing amine oxidoreductase
Pathways
Biological processes and signaling networks where the Il4i1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nasal type extranodal NK-/T-cell lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
- androgenic alopecia
- epileptic seizure
role in cell
- proliferation
- differentiation
- expression in
- production in
- molecular cleavage in
- activation
- non-proliferation
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- Extracellular Space
- lysosome
- immunological synapses
- granules
- sperm midpiece
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il4i1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular amino acid catabolic process
- regulation of B cell differentiation
- adaptive immune response
- tyrosine catabolic process
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of regulatory T cell differentiation
- negative regulation of T cell mediated immune response to tumor cell
- tryptophan catabolic process
- L-phenylalanine catabolic process
- negative regulation of T cell proliferation
- tryptophan catabolic process to indole-3-acetate
- negative regulation of T cell activation
- regulation of adaptive immune response
Cellular Component
Where in the cell the gene product is active
- sperm midpiece
- acrosomal vesicle
- extracellular region
- immunological synapse
- lysosome
Molecular Function
What the gene product does at the molecular level
- polyamine oxidase activity
- protein binding
- L-amino-acid oxidase activity