Tnfrsf17 Gene Summary [Rat]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf17 |
| Official Name | TNF receptor superfamily member 17 [Source:RGD Symbol;Acc:1304703] |
| Ensembl ID | ENSRNOG00000021987 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 17 |
| Synonyms | BCM, BCMA, BCMA antigen, CD269, TNFR4, TNF receptor superfamily member 17, Tnfrsf13, TNFRSF13A, tumor necrosis factor receptor superfamily member 17, tumor necrosis factor receptor superfamily, member 17, tumour necrosis factor receptor superfamily member 17, tumour necrosis factor receptor superfamily, member 17 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnfrsf17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- cytoplasmic domain
- BCMA, TALL-1 binding
- transmembrane domain
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Tnfrsf17 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- relapsed multiple myeloma
- epithelial cancer
- cancer
- colorectal cancer
- hepatocellular carcinoma
- psoriasis
- plasma cell myeloma
- refractory multiple myeloma
- skin cancer
- refractory relapsed multiple myeloma
role in cell
- quantity
- proliferation
- apoptosis
- expression in
- activation in
- number
- growth
- binding
- activation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear Golgi regions
- cell surface
- cell periphery
- intracellular space
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnfrsf17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tumor necrosis factor-mediated signaling pathway
- signal transduction
- lymphocyte homeostasis
- adaptive immune response
Cellular Component
Where in the cell the gene product is active
- membrane
- endomembrane system
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity