Anks6 Gene Summary [Rat]
Enables identical protein binding activity. Predicted to be involved in innate immune response. Predicted to act upstream of or within several processes, including determination of left/right symmetry; heart development; and in utero embryonic development. Predicted to be located in ciliary inversin compartment. Predicted to be active in cytoplasm. Used to study polycystic kidney disease; proteinuria; and uremia. Human ortholog(s) of this gene implicated in nephronophthisis 16. Orthologous to human ANKS6 (ankyrin repeat and sterile alpha motif domain containing 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anks6 |
| Official Name | ankyrin repeat and sterile alpha motif domain containing 6 [Source:RGD Symbol;Acc:3334] |
| Ensembl ID | ENSRNOG00000023309 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and sterile alpha motif domain containing 6 |
| Synonyms | 2210417J20Rik, ANKRD14, ankyrin repeat and sterile alpha motif domain containing 6, ankyrin repeat and sterile α motif domain containing 6, b2b1801.1Clo, Gm635, NPHP16, PKDR1, SamCystin, SAMD6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Anks6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- Ankyrin repeats (many copies)
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- Ankyrin repeats (3 copies)
- protein binding
- identical protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- nephronophthisis type 16
- situs inversus
- congenital heart disease
- periportal fibrosis
- overriding aorta
- situs ambiguus
- situs inversus totalis
- portal hypertension
- atrioventricular septal defect
role in cell
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Anks6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- in utero embryonic development
- kidney development
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding