Srsf3 Gene Summary [Rat]
Enables sequence-specific mRNA binding activity. Predicted to be involved in gene expression and regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be active in nuclear speck. Orthologous to human SRSF3 (serine and arginine rich splicing factor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Srsf3 |
| Official Name | serine and arginine rich splicing factor 3 [Source:RGD Symbol;Acc:1309233] |
| Ensembl ID | ENSRNOG00000000520 |
| Bio databases IDs | |
| Aliases | serine and arginine rich splicing factor 3 |
| Synonyms | serine and arginine-rich splicing factor 3, SFRS3, Similar to splicing factor, arginine/serine-rich 3, Splicing Factor SFR3, SRp20, X16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Srsf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginine serine dipeptide repeat domain
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- protein binding activity, bridging
- enzyme binding
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver neoplasia
- epithelial neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- asthma
- stomach neoplasm
role in cell
- invasion by
- expression in
- degradation in
- apoptosis
- proliferation
- accumulation in
- migration
- quantity
- cell viability
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ribosome
- spliceosomes
- inner nuclear membrane
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Srsf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- primary miRNA processing
- regulation of nuclear mRNA splicing, via spliceosome
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pre-mRNA binding
- RNA binding
- protein binding
- phospholipase binding
- primary miRNA binding