Scyl1 Gene Summary [Rat]
Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within inflammatory response; neuron differentiation; and protein localization. Predicted to be located in cis-Golgi network; cytosol; and endoplasmic reticulum-Golgi intermediate compartment. Predicted to be part of COPI vesicle coat. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 21. Orthologous to human SCYL1 (SCY1 like pseudokinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scyl1 |
| Official Name | SCY1 like pseudokinase 1 [Source:RGD Symbol;Acc:1307330] |
| Ensembl ID | ENSRNOG00000023668 |
| Bio databases IDs | |
| Aliases | SCY1 like pseudokinase 1 |
| Synonyms | 2810011O19Rik, GKLP, HT019, mdf, mfd, NKTL, NTKL, P105, SCAR21, SCY1-like 1 (S. cerevisiae), SCY1 like pseudokinase 1, TAPK, TEIF, TRAP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scyl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Protein Kinases, catalytic domain
- kinase-like domain
- coiled-coil domain
- protein binding
- protein-tyrosine kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- astrocytosis
- autosomal recessive spinocerebellar ataxia type 21
- hereditary disorder
- psoriatic arthritis
- motor neuron disease
- growth failure
- non-insulin-dependent diabetes mellitus
- paralysis
- SCYL1-related disorder
- motor dysfunction
role in cell
- differentiation
- number
- size
- degeneration
- abnormal morphology
- atrophy
- switching
- loss
- diameter
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- filamentous network
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- cis Golgi networks
- nuclear pores
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scyl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- retrograde vesicle-mediated transport, Golgi to ER
- spinal cord motor neuron differentiation
- protein localization
- neuron development
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cis-Golgi network
- cytoplasm
- membrane
- cytosol
- Golgi apparatus
- endoplasmic reticulum-Golgi intermediate compartment
- COPI vesicle coat
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA binding
- protein tyrosine kinase activity
- cadherin binding