Arhgap33 Gene Summary [Rat]
Predicted to enable GTPase activator activity and protein kinase binding activity. Involved in regulation of dendritic spine morphogenesis and response to toxic substance. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human ARHGAP33 (Rho GTPase activating protein 33). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap33 |
| Official Name | Rho GTPase activating protein 33 [Source:RGD Symbol;Acc:2318374] |
| Ensembl ID | ENSRNOG00000024677 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 33 |
| Synonyms | NOMA-GAP, Rho GTPase activating protein 33, SNX26, TCGAP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgap33 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- protein kinase binding
- GTPase activator
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- GTPase Activating Protein domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- transporter
- Src Homology 3 domain superfamily
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- epithelial cancer
- non-small cell lung cancer
- bipolar disorder
- juvenile rheumatoid arthritis
- plasma cell myeloma
- glioblastoma
- sickle cell anemia
- asthma
- Crohn disease
regulates
- 2-deoxyglucose
- SLC2A4
role in cell
- outgrowth
- branching
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- perinuclear region
- cytosol
- dendritic spines
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgap33 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic spine morphogenesis
- small GTPase mediated signal transduction
- protein transport
- response to toxin
Cellular Component
Where in the cell the gene product is active
- cell cortex
- dendritic spine
- actin cytoskeleton
- cytosol
- macromolecular complex
- Golgi apparatus
- plasma membrane
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- GTPase activator activity
- phosphatidylinositol binding