Snx17 Gene Summary [Rat]
Predicted to enable low-density lipoprotein particle receptor binding activity and phosphatidylinositol binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to act upstream of or within circulatory system development; kidney development; and receptor-mediated endocytosis. Predicted to be located in Golgi apparatus; cytosol; and endosome membrane. Predicted to be part of protein-containing complex. Predicted to be active in early endosome. Orthologous to human SNX17 (sorting nexin 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snx17 |
| Official Name | sorting nexin 17 [Source:RGD Symbol;Acc:1306424] |
| Ensembl ID | ENSRNOG00000026884 |
| Bio databases IDs | |
| Aliases | sorting nexin 17 |
| Synonyms | 5830447M19Rik, b2b1625.1Clo, D5Ertd260e, mKIAA0064, sorting nexin 17, XIG5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Snx17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM domain
- Ubl1_cv_Nsp3_N-like
- Sorting Nexin 17 FERM C-terminal domain
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- low-density lipoprotein receptor binding
- Pleckstrin homology-like domain
- phosphatidylinositol binding
- PX domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- albuminuria
- hyperlipidemia
- congenital heart disease
- bipolar disorder
- urinary bladder stone
- microalbuminuria
role in cell
- expression in
- degradation in
- migration
- conjugation
- loss in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membrane-bounded organelle
- Nucleus
- endosomes
- vesicles
- Golgi Apparatus
- immunological synapses
- cytosol
- endosomal membrane
- early endosomes
- cytoplasmic vesicles
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Snx17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cholesterol catabolic process
- signal transduction
- aorta development
- kidney development
- coronary vasculature development
- endosomal transport
- regulation of endocytosis
- intracellular protein transport
- receptor-mediated endocytosis
- endocytic recycling
- cardiac septum development
Cellular Component
Where in the cell the gene product is active
- early endosome
- endosome
- intracellular membrane-bounded organelle
- membrane
- cytosol
- cytoplasmic vesicle
- endosome membrane
- macromolecular complex
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- low-density lipoprotein particle receptor binding
- phosphatidylinositol binding
- receptor binding