Rnf13 Gene Summary [Rat]
Predicted to enable JUN kinase binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of JNK cascade; protein autoubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including endoplasmic reticulum; late endosome membrane; and nucleoplasm. Predicted to be active in lysosomal membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 73. Orthologous to human RNF13 (ring finger protein 13). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf13 |
| Official Name | ring finger protein 13 [Source:RGD Symbol;Acc:1594062] |
| Ensembl ID | ENSRNOG00000029209 |
| Bio databases IDs | |
| Aliases | ring finger protein 13 |
| Synonyms | 2010001H16RIK, DEE73, EIEE73, LOC100909807, ring finger protein 13, RZF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rnf13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- JUN kinase binding
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- PA domain
- RING-type zinc-finger
- PA
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- PHD finger superfamily
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatic steatosis
- fibrosis
- oral lichen planus
- early infantile epileptic encephalopathy type 73
- nonalcoholic steatohepatitis
- oral leukoplakia
- nephritis
- neonatal late-onset sepsis
role in cell
- expression in
- apoptosis
- activation in
- radiosensitivity
- abnormal morphology
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- endosomes
- Endoplasmic Reticulum
- cytosol
- mitochondrial outer membrane
- lysosome membrane
- endosomal membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rnf13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organelle localization
- positive regulation of JNK cascade
- ubiquitin-dependent protein catabolic process
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- late endosome membrane
- nuclear inner membrane
- endosome
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- endoplasmic reticulum
- lysosomal membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding
- JUN kinase binding