Alas1 Gene Summary [Rat]
Enables 5-aminolevulinate synthase activity. Involved in several processes, including cellular response to insulin stimulus; response to herbicide; and response to nickel cation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrial matrix. Biomarker of porphyria and pulmonary hypertension. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alas1 |
| Official Name | 5'-aminolevulinate synthase 1 [Source:RGD Symbol;Acc:68392] |
| Ensembl ID | ENSRNOG00000056596 |
| Bio databases IDs | |
| Aliases | 5'-aminolevulinate synthase 1 |
| Synonyms | 5'-aminolevulinate synthase 1, ALA-S, ALAS3, ALAS-H, ALAS-N, aminolevulinic acid synthase 1, Delta Alas, Delta Aminolevulinate Synthase, MIG4, δ Alas, δ Aminolevulinate Synthase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alas1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 8-amino-7-oxononanoate synthase
- 5-aminolevulinic acid synthase
- 5-aminolevulinate synthase
- 5-aminolevulinate synthase presequence
- cysteine-proline dipeptide repeat motif
- AAT_I
- enzyme
- protein binding
- Aminotransferase class I and II
- identical protein binding
Pathways
Biological processes and signaling networks where the Alas1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Huntington disease
- depressive disorder
- endometrial cancer
- porphyria variegata
- acute porphyria
- colorectal cancer
- acute intermittent porphyria
- delta-aminolevulinate dehydratase porphyria
- Crohn disease
role in cell
- expression in
- binding in
- oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Alas1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heme O biosynthetic process
- heme biosynthetic process
- heme a biosynthetic process
- hemoglobin biosynthetic process
- erythrocyte development
- protoporphyrinogen IX biosynthetic process
- heme b biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- identical protein binding
- protein binding
- 5-aminolevulinate synthase activity