Samsn1 Gene Summary [Rat]
Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in several processes, including negative regulation of B cell activation; negative regulation of adaptive immune response; and negative regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Samsn1 |
| Official Name | SAM domain, SH3 domain and nuclear localization signals, 1 [Source:RGD Symbol;Acc:620926] |
| Ensembl ID | ENSRNOG00000030930 |
| Bio databases IDs | |
| Aliases | SAM domain, SH3 domain and nuclear localization signals, 1 |
| Synonyms | AF1651387, HACS1, LOC388813, Nash, NASH1, SAM domain, SH3 domain and nuclear localization signals 1, SAM domain, SH3 domain and nuclear localization signals, 1, SASH2, SH3D6B, SLy2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Samsn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- phosphotyrosine binding
- Lymphocyte signaling adaptor protein
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- prostate cancer
- plasma cell myeloma
- sepsis
- flu
- peripheral arterial disease
- polycystic kidney disease
- COVID-19
- chronic periodontal disease
- Down syndrome
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Samsn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of adaptive immune response
- negative regulation of B cell activation
- negative regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- ruffle
- cytosol
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- RNA binding