Scfd1 Gene Summary [Rat]
Enables syntaxin binding activity. Involved in Golgi vesicle transport; regulation of ER to Golgi vesicle-mediated transport; and response to hypoxia. Located in Golgi-associated vesicle. Orthologous to human SCFD1 (sec1 family domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scfd1 |
| Official Name | sec1 family domain containing 1 [Source:RGD Symbol;Acc:619828] |
| Ensembl ID | ENSRNOG00000031203 |
| Bio databases IDs | |
| Aliases | sec1 family domain containing 1 |
| Synonyms | 3110021P21RIK, C14orf163, FKSG23, RA410, rSly1, Sec1 family domain containing 1, SLY1, SLY1P, STXBP1L2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scfd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- Sec1 family
- transporter
- syntaxin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amyotrophic lateral sclerosis
- hemolysis
- susceptibility to amyotrophic lateral sclerosis
- infection by HIV-1
role in cell
- autophagy in
- binding in
- assembly
- autophagy
- transport
- fusion in
- fusion
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Golgi Apparatus
- cytosol
- endoplasmic reticulum membrane
- cis Golgi networks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scfd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- response to hypoxia
- regulation of protein transport
- regulation of ER to Golgi vesicle-mediated transport
- retrograde vesicle-mediated transport, Golgi to ER
- cell morphogenesis
- post-Golgi vesicle-mediated transport
- intracellular protein transport
- response to toxin
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cis-Golgi network
- Golgi cisterna membrane
- cytosol
- Golgi membrane
- Golgi-associated vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding