Cxxc5 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor binding activity; methyl-CpG binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of canonical NF-kappaB signal transduction; and regulation of generation of precursor metabolites and energy. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CXXC5 (CXXC finger protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cxxc5 |
| Official Name | CXXC finger protein 5 [Source:RGD Symbol;Acc:1359466] |
| Ensembl ID | ENSRNOG00000032878 |
| Bio databases IDs | |
| Aliases | CXXC finger protein 5 |
| Synonyms | 4930415K17Rik, CF5, CXXC finger 5, CXXC finger protein 5, HSPC195, RINF, WID |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cxxc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- methyl-CpG binding
- transcription factor binding
- CXXC zinc finger domain
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- macrodactyly
- adenomyosis
- breast carcinoma
- rotator cuff injury
- mature B-cell neoplasia
- serous ovarian adenocarcinoma
- serous ovarian cancer
- metabolic syndrome X
- plasma cell neoplasm
- B cell cancer
role in cell
- expression in
- migration
- formation
- differentiation
- transactivation in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cxxc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of generation of precursor metabolites and energy
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- sequence-specific DNA binding
- methyl-CpG binding