Cacna1h Gene Summary [Rat]
Enables low voltage-gated calcium channel activity. Involved in calcium ion import; positive regulation of cardiac muscle cell contraction; and steroid hormone biosynthetic process. Located in dendrite and perikaryon. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in childhood absence epilepsy and primary hyperaldosteronism. Orthologous to human CACNA1H (calcium voltage-gated channel subunit alpha1 H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacna1h |
| Official Name | calcium voltage-gated channel subunit alpha1 H [Source:RGD Symbol;Acc:68943] |
| Ensembl ID | ENSRNOG00000033893 |
| Bio databases IDs | |
| Aliases | calcium voltage-gated channel subunit alpha1 H |
| Synonyms | alpha13.2, Alpha 1H T-type Calcium Channel subunit, CACNA1HB, calcium channel, voltage-dependent, T type, alpha 1H subunit, calcium channel, voltage-dependent, T type, α 1H subunit, calcium voltage-gated channel subunit alpha1 H, CAV3.2, ECA6, EIG6, HALD4, MNCb-1209, α 1H T-type Calcium Channel subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cacna1h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- intracellular loop
- Ion transport protein
- low voltage-gated calcium channel
- protein binding
- voltage-gated ion channel
- ion channel
- Polycystin cation channel
Pathways
Biological processes and signaling networks where the Cacna1h gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Androgen Signaling
- Calcium Signaling
- CCR5 Signaling in Macrophages
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Mitochondrial Dysfunction
- Netrin Signaling
- nNOS Signaling in Skeletal Muscle Cells
- Opioid Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Sperm Motility
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epilepsy
- seizures
- localization-related epilepsy
- partial seizure
- alcoholism
- schizophrenia
- alcohol abuse
- susceptibility to idiopathic generalized epilepsy type 6
- osteoarthritis
- obesity
regulates
- adenosine triphosphate
- insulin
- Ca2+
- CYP11B2
- ERK
- aldosterone
- luciferase reporter gene
- synthetic promoter
- inorganic cation
- hydrocortisone
role in cell
- cell death
- cell viability
- apoptosis
- expression in
- transmembrane potential
- production in
- fusion
- neuritogenesis
- abnormal morphology
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- caveolae
- sarcolemma
- Z line
- perikaryon
- dendrites
- presynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cacna1h gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- calcium ion import
- regulation of membrane potential
- cortisol biosynthetic process
- muscle contraction
- myoblast fusion
- positive regulation of acrosome reaction
- regulation of heart contraction
- cellular response to hormone stimulus
- aldosterone biosynthetic process
- cellular response to potassium ion
Cellular Component
Where in the cell the gene product is active
- membrane
- voltage-gated calcium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- protein binding
- high voltage-gated calcium channel activity
- metal ion binding
- voltage-gated ion channel activity
- low voltage-gated calcium channel activity