Cacna1h Gene Summary [Mouse]

Voltage-dependent Ca(2+) channels mediate the entry of Ca(2+) ions into excitable cells and are involved in a variety of Ca(2+)-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. The protein encoded by this gene is an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

Details

Type
Protein Coding
Official Symbol
Cacna1h
Official Name
calcium channel, voltage-dependent, T type, alpha 1H subunit [Source:MGI Symbol;Acc:MGI:1928842]
Ensembl ID
ENSMUSG00000024112
Bio databases IDs NCBI: 58226 Ensembl: ENSMUSG00000024112
Aliases calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms alpha13.2, Alpha 1H T-type Calcium Channel subunit, CACNA1HB, calcium channel, voltage-dependent, T type, alpha 1H subunit, calcium channel, voltage-dependent, T type, α 1H subunit, calcium voltage-gated channel subunit alpha1 H, CAV3.2, ECA6, EIG6, HALD4, MNCb-1209, α 1H T-type Calcium Channel subunit
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cacna1h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • voltage-gated calcium channel
  • intracellular loop
  • Ion transport protein
  • low voltage-gated calcium channel
  • protein binding
  • voltage-gated ion channel
  • ion channel
  • Polycystin cation channel

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • ethosuximide
  • HNRNPL
  • KDM5B
  • isradipine
  • cinnarizine
  • flunarizine
  • bepridil
  • zonisamide
  • mibefradil
  • VIRMA
disease
  • epilepsy
  • seizures
  • localization-related epilepsy
  • partial seizure
  • alcoholism
  • schizophrenia
  • alcohol abuse
  • susceptibility to idiopathic generalized epilepsy type 6
  • osteoarthritis
  • obesity
regulated by
regulates
  • adenosine triphosphate
  • insulin
  • Ca2+
  • CYP11B2
  • ERK
  • aldosterone
  • luciferase reporter gene
  • synthetic promoter
  • inorganic cation
  • hydrocortisone
role in cell
  • cell death
  • cell viability
  • apoptosis
  • expression in
  • transmembrane potential
  • production in
  • fusion
  • neuritogenesis
  • abnormal morphology
  • hypertrophy

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • glutaminergic synapse
  • cellular membrane
  • presynaptic membrane
  • postsynaptic membrane
  • caveolae
  • sarcolemma
  • Z line
  • perikaryon
  • dendrites
  • presynaptic terminals

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cacna1h gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • muscle organ development
  • calcium ion import
  • regulation of membrane potential
  • cortisol biosynthetic process
  • muscle contraction
  • myoblast fusion
  • positive regulation of acrosome reaction
  • regulation of heart contraction
  • cellular response to hormone stimulus
  • aldosterone biosynthetic process
  • cellular response to potassium ion

Cellular Component

Where in the cell the gene product is active
  • membrane
  • voltage-gated calcium channel complex
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • scaffold protein binding
  • protein binding
  • high voltage-gated calcium channel activity
  • metal ion binding
  • voltage-gated ion channel activity
  • low voltage-gated calcium channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.