Cr2

Predicted to enable several functions, including complement receptor activity; immunoglobulin receptor binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including B cell activation; negative regulation of complement activation, classical pathway; and type I interferon-mediated signaling pathway. Predicted to act upstream of or within with a negative effect on complement activation, alternative pathway. Predicted to act upstream of or within several processes, including cellular response to lipopolysaccharide; immunoglobulin mediated immune response; and skeletal system development. Located in cell surface and extracellular space. Human ortholog(s) of this gene implicated in common variable immunodeficiency 7; nasopharynx carcinoma; and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Cr2 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Cr2 gene, providing context for its role in the cell.